A REAL WAR-TIME PHYSICIAN

Professor Didier Raoult is above all a true clinician, an observer, a researcher, a decision-maker. He implements in full conscience what his vast experience taught him. Facing emergency, he does not wait around for committees to multiply, he doesn’t care for useless meetings and stupid jealousies among colleagues in ministry cabinets, nor on Parisian TV platforms. No more does he care for information gathered by a few physician-journalists or ministers willing to reassure us without knowing anything.

Authentic clinicians, physicians, pharmacists and professors of therapeutic chemistry work in the field. They are women and men, team leaders who work in close contact with patients, and are weary of diktats from administrative offices, too often indirectly working for the pharmaceutical industry or with TV shows.

Didier Raoult upholds a rigorous ethic. He is faithful to the Hippocratic oath that he swore in 1981. He doesn’t care about criticism. His vocation is to serve the health of patients seating in front of him, as well as serving public health. It is indeed easy to rethink public health far removed from reality, with an approach exclusively focused on statistics.

A large experience close to patients, international contacts (1) and references (2) were sufficient for him to decide, back on February 25th, 2020, to treat coronavirus patients with medications over which he has perfect mastery.

Because it’s a war-like situation, professor Raoult did not wait for statisticians and their meta-analysis (3) or randomized studies. For the scientific needs of such studies, patients are picked randomly to test new medications constantly the pharmaceutical industry, now firmly established in health centers and hospitals, constantly seeks to introduce onto the market. This is what is happening in cancer hospitals, which I am very familiar with. They are invaded with “early” clinical studies, which are really therapeutic testing.

Certainly, such treatments are financially rewarding, more so than disease prevention would be. And it shows, since the development of disease prevention is still at its infancy in all areas of medical expertise (4).

Do mathematicians to whom select studies are handed over know that they are tasked with obtaining results that sponsors hope for, and that what doesn’t fit these hopes won’t be published?

On the battlefield, we don’t need mathematicians, or only to count the dead and the injured.

Now, health authorities are imposing treatment protocols as defined by Big Pharma (it yields more money and it is covered by health insurance and social security). Such treatments are meant to cure lifestyle-built or made-up and generalized pathologies such as osteoporosis, menopause, arthrosis, old age, all-grade fevers, any level of pain, psychological or behavioral issues… and they reject homeopathic treatments that cost nothing and can avoid heavy treatments!

Firstly, Chloroquine is a medication that has proven its usefulness for many indications. From 1955 onward, it was used as a synthetic anti-malaria medication. Derived from quinine, it is extracted from cinchona bark (5). It was the first efficient medication against malaria, whether used preventatively or as a treatment. Chloroquine was well known and used by military and colony physicians during their missions. It costs virtually nothing.

The French College of Medical Pharmacology explains its wise prudence: “This is medication with a narrow therapeutic range. If overdosed, it can trigger either heart arrhythmia, or sensory issues constituting cinchonism [also called quinism].” (6)

The French Pharmacology and Therapeutics Society responds to questions on its website, and provides scientific references.

For example, to the question “Chloroquine, Hydroxychloroquine, Nivaquine, Plaquenil… what are they? », it responds:
“In France, [chloroquine] is distributed under the name Nivaquine®.  Derivative of chloroquine, hydroxychloroquine (distributed as Plaquenil®) is used for long term treatment of some auto-immune diseases such as lupus or rheumatoid arthritis. These two medications are said to have a “narrow therapeutic range”, i.e. the efficient dosage and the toxic dosage are relatively close. Therefore, it is essential to carefully follow the recommended use so as to avoid serious side effects, particularly cardiovascular side effects. Under no circumstance should a patient take this medication without medical prescription.”  This is exactly what professor Raoult and his team keep asserting.

Note that hydroxychloroquine is distyributed under different names in various countries; for example Plaquenil® in France, and Remdesivir® in the United States.

When confronted to Coronavirus 2, healthcare providers try to reach two urgent goals: reducing the viral load, and with it, contagiousness.

1/ Avoiding viral replication or multiplication

Upon viral replication, the virus could reach 10,000 to 100,000 viral particles, which first penetrate the cells lining the upper airways: nose, throat and pharynx.
Then, first signs of illness appear that are well known in the case of the flu: loss of taste and of the sense of smell (also called “anosmia”).
We also know that these signs are common, although weaker, with early onset neurodegenerative diseases such as Alzheimer’s or Parkinson’s, and that they are difficult to pinpoint. International publications have linked such signs to the incidence of zinc deficiency (7), an essential oligoelement, 98% of which is located in the cells. This element is the most important after iron to avoid anemia. Zinc deficiency is correlated to weak albumin rates in the blood, and to dairy consumption in excess (8). This is common in the elderly (50% are deficient), who are pressured into eating a lot of dairy based on pseudo-scientific arguments.

2/ Avoid lung surperinfection

What is dangerous, is that viral particles of Covid-19 penetrate respiratory pathways towards the trachea, below onto the bronchus (pathway to the lungs), to the bronchiole and onto the air sacs (alveoli). If that happens, the mucus that is fabricated becomes be thicker, the cells with thin lashes aren’t be able to function optimally; expectorating becomes be difficult, hence the dry, repetitive and tiring cough.

Follows that fever doesn’t suffice to contain negative effects of the virus. A real storm of inflammatory cells (cytokines and chemokines) aggravated by zinc deficiency is released by an overwhelmed immune system

Breathing pathways get infected, hence the necessary precaution of associating hydroxychloroquine with an antibiotic treatment known for its anti-infectious and anti-viral properties in respiratory infections: Azithromycine.

Taken orally, hydroxychloroquine (which is 3 times less toxic than chloroquine) is absorbed quickly through the digestive tract and passes into the blood flow.

It reaches its maximum rate within one to two hours. It binds to plasma proteins such as albumin (hence the necessity to eat healthy (9)) to pass through the liver, where it is metabolized by enzymes that are well-known by specialists: cytochromes P450.

Molecules pass through the placenta and into breastmilk. It doesn’t seem dangerous to the pregnant woman nor to her child. It is later eliminated by the kidney.

The fact that ANSES (French National Authority for Sanitary and Food Security) gave its authorization to add hydroxychloroquine to the list of poisonous substances one month to the beginning of the pandemic remains mysterious.

Hydroxychloroquine facilitates the entry of zinc into the cell, triggering an anti-viral effect by blocking the replication of the Coronavirus RNA. The following link contains very specific explanations on that fact:

 https://www.youtube.com/watch?v=U7F1cnWup9M&feature=youtu.be

From 2010 and then since 2014, two publications, one from the Netherlands, and one by collaborating University of Oklahoma USA and University of Xuzhou in China, provided high level scientific proof:

– Zinc inhibits Coronavirus and Arterivirus RNA Polymerase Activity in vitro and Zinc Ionophores Block the Replication of these virus in Cell culture.

– Chloroquine is a Zinc Ionophore.

Already then, links between hydroxychloroquine molecule and zinc already appeared as essential. Moreover, it was demonstrated that this oligoelement also acts as inhibitor of pro-inflammatory molecules (10).

Therefore, zinc supplementation can be necessary, especially in the elderly and fragile patients. It is all the more needed that additional medical conditions can necessitate other medications that lower blood zinc levels (11).

The recommended dosage is 5ml or 5mg per day in a glass of water throughout the whole epidemic, and particularly at the first signs of weakening of the senses of smell and taste.

Professor Raoult explains: “Assumedly, the hydroxychloroquine molecule has two effects precipitating the elimination of the virus. First, it modifies the acidic environment of the cell’s vacuole. This little pocket filled with fluid protected by a membrane is like a nest for the virus… [Hydroxychloroquine] disturbs the quiet ecosystem of this refuge. [As a consequence,] enzymes usually involved in the cell machinery the virus uses to replicate no longer can play their role [of replication assistant]. Hydroxychloroquine also supports apoptosis, i.e. programmed cell death, a genetic mechanism protecting the body from infection by commanding infected cells to autodestruct.”

To the question “What happens to the people you screen?”, he responds:
“Our protocol is solid. We look at clinical signs of the disease, and proceed to a pulmonary scanner “with a weak irradiation dose”, as do the Chinese. That is because a portion of contaminated people do not present obvious clinical signs, but do present pulmonary lesions that could get worse if they go untreated. They are the ones that we treat with what we consider to be the only treatment available these days. Two days later, they are invited for an E.C.G. Cardiovascular risk is the most serious side effect. This is an ambulatory treatment, but naturally, most serious patients are hospitalized.”

As for colleagues or mathematicians who demand randomized studies, where a group of Covid-19 patients is treated with the two mediations, and the other group gets placebo, would they accept to be chosen randomly to take a placebo, or do they prefer to let other patients take that risk? In a war-like time, it is a military-like organization professor Didier Raoult organized with such amazing efficiency.

Let us honor our colleague and his whole team (12), and all the healthcare staff, devoted night and day throughout the world to save such weakened lives.

Day after day, we are looking out for your health.
Professor Henri Joyeux

1 – Chen Caixian, a Chinese researcher, asserted on Feburary 12th: “According to our analysis, in an in-vitro environment, chloroquine has good antiviral properties against coronavirus”.
2 – In 2005 in Canada, research finds that in cell culture: “Chloroquine is a potent inhibitor of SARS coronavirus infection and spread”. Martin J Vincent and all- Virol J. 2005; 2: 69. Published online 2005 Aug 22. doi: 10.1186/1743-422X-2-69 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/
See also in India, January 2020, reference from the Indian Journal of Pharmacology : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074432/

3 – Live meta-analysis allow synthesis of results for every treatment, added to an assessment of the level of proof supporting the studies, plus the degree of certainty of the synthesis (adapted from GRADE). https://sfpt-fr.org/actualites.
4 – Vaccination qualifies as preventative treatment, except in the case of abusive vaccination at ages when children’s immune system is not yet mature. Many vaccines impose on children a dangerous adjuvant: aluminum. The most telling example is the vaccination against hepatitis B at age two months in France (or at birth in the U.S.A.), or vaccination against HPV (human papillomavirus) from age 9 for boys and girls alike, without 100% certainty that it will prevent cervical cancer or ENT zone cancers.

5 – Cinchona is a little tree that keeps its leaves year-round. This tree originally comes from Ecuador, is very well known in Peru, and an endangered species. In 1649, King of France Louis the XIV is said to have healed from a tenacious fever thanks to the Jesuit herb containing quinine extracted from the tree’s bark.  Later, his son also healed thanks to this powder, and had a document published about this treatment by his court’s apothecary.
6 – Here are the unpleasant effects of quinine: auditory issues with tinnitus, vertigo, migraines, nausea, vision loss, amaurosis (a decrease in visual acuity without detectable anatomical lesion), and even risks of anemia due to the destruction of red blood cell, that could result in kidney failure.
7 – De Benoist B, Darnton-Hill I, Davidsson L et coll. “Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators.” Food Nutr Bull 2007;28(3 Suppl):S480-4.
8 – In excess, calcium impedes on zinc absorption. See the excellent article Anthony Bertou on his website http://www.sante-et-nutrition.com/deficit-zinc/
9 – Combine at least one organic egg lightly cooked to the yolk remains runny to zinc, which you can find in sea food, lentils, walnuts, seeds and many  thoroughly chewed season’s fruits that maintain the digestive microbiome.
10 – https://www.ncbi.nlm.nih.gov/pubmed/28513591 Zinc is a potent and specific inhibitor of IFN-λ3 signaling. Read SA & all
11 – In cardiology, diuretics, calcium antagonists, inhibitors of enzyme conversion and also glucocorticoids, and some contraceptives in young subjects.
12 – His last publication dated March 27th reports the results of his treatment as applied to 80 patients infected with Covid-19 and treated for respiratory issues.

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